The hydroxyl radical scavenging action of green tea tannin given orally to rats with experimental renal failure was examined by using the urinary methylguanidine excretion as an index. In rats given 2 mg of a green tea tannin mixture, the urinary methylguanidine excretion was significantly decreased or had a tendency to decrease. (-)-Epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, effected a decrease in the urinary methylguanidine excretion in rats at a dose as low as 0.25 mg, suggesting a hydroxyl radical scavenging action.
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Yokozawa et al. (1992) studied this question.
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