Bone tissue engineering is one of the vital approaches used to tackle bone defects in the past decades. This approach is a risk-free alternative to conventional bone graft substitutes, such as autografts, allografts, and xenografts. Silicate bioceramics have improved mechanical properties and biological performances compared with phosphate-based ceramics. However, their brittleness limits their application in load-bearing sites. Therefore, silicate-based ceramics have been used in combination with several polymers in the form of a composite scaffold. This review article summarizes the influence of silicate ceramics on the mechanical, cytocompatibility, and bioactivity of polymeric-based scaffold for bone tissue engineering application.
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Ahmadipour et al. (2020) studied this question.
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