In modernization nitrogen containing heterocyclic compounds and their derivatives has attracted great interest due to their efficacious biological and pharmacological properties. The moiety of piperazines and substituted aryl piperazines were found to present in compounds aim at evaluating new entities that possess anti-microbial, anti-tubercular, anticonvulsant, anti-depressant, anti-malarial and anti-inflammatory activities. Piperazines show a broad range of activities and are found in many potent biologically active compounds such as thiothixene and pimozide (anti-psychotics), Loxapine (schizophrenia), Clozapine (Atypical anti-psychotics). The modifications in the moiety of piperazine ring shows high efficacy with better potency and lesser toxicity. This review focused on multifarious biological activities related to piperazines and its derivatives.
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Verma et al. (2017) studied this question.
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