The specification and wiring of mammalian cutaneous low‐threshold mechanoreceptors

The mammalian cutaneous low‐threshold mechanoreceptors ( LTMRs ) are a diverse set of primary somatosensory neurons that function to sense external mechanical force. Generally, LTMRs are composed of Aβ‐ LTMRs , Aδ‐ LTMRs , and C‐ LTMRs , which have distinct molecular, physiological, anatomical, and functional features. The specification and wiring of each type of mammalian cutaneous LTMRs is established during development by the interplay of transcription factors with trophic factor signalling. In this review, we summarize the cohort of extrinsic and intrinsic factors generating the complex mammalian cutaneous LTMR circuits that mediate our tactile sensations and behaviors. WIREs Dev Biol 2016, 5:389–404. doi: 10.1002/wdev.229 This article is categorized under: Gene Expression and Transcriptional Hierarchies > Cellular Differentiation Signaling Pathways > Cell Fate Signaling Nervous System Development > Vertebrates: Regional Development