We evaluated β-lactam-resistant baseline Enterobacterales species and Pseudomonas aeruginosa lower respiratory tract isolates collected during the ASPECT-NP phase 3 clinical trial evaluating the safety and efficacy of ceftolozane-tazobactam compared with meropenem for the treatment of nosocomial pneumonia in ventilated adults. Isolates were subjected to whole-genome sequencing, quantitative real-time PCR for quantification of the expression levels of β-lactamase and efflux pump genes, and Western blot analysis for the detection of OprD ( P. aeruginosa only).
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