Key result
Primary pleural angiosarcoma mimics mesothelioma and requires endothelial markers for accurate diagnosis.
Why the study?
Primary pleural angiosarcoma is a rare tumor that mimics mesothelioma clinically and radiologically, complicating its diagnosis.
Case Report (n=1)
No
Primary pleural angiosarcoma is a rare, aggressive tumor that can mimic mesothelioma clinically and radiologically, requiring careful immunohistochemical evaluation for diagnosis.
Consider angiosarcoma in mesothelioma-like pleural tumors via endothelial markers; case reports leave open standardized diagnostic criteria and therapies.
Primary pleural angiosarcoma is a rare and clinically aggressive tumor. Patients usually present with chest pain, dyspnea, hemoptysis and/or cough. Radiologic studies reveal diffuse pleural thickening and pleural effusion with or without mass lesion. The clinical and radiological features both resemble those of mesothelioma, and its definite diagnosis requires careful histologic examination. However, frequent epithelioid feature and immunoreactivity to cytokeratin in primary pleural angiosarcoma further complicate the pathologic diagnosis. The use of proper immunohistochemical stains is often needed to support endothelial differentiation in the tumor cells and to exclude metastatic carcinoma and mesothelioma. We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status.
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Kao et al. (2011) conducted a case report in Primary pleural angiosarcoma (n=1). Diagnostic evaluation and multidisciplinary treatment was evaluated. Primary pleural angiosarcoma is a highly malignant disease that mimics mesothelioma and requires careful pathologic examination with endothelial markers for accurate diagnosis.
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