Overdosage with 280 mg nifedipine, verified by plasma nifedipine levels, led in a 23-year-old female patient with advanced renal insufficiency to features of marked vasodilation. Despite profound hypotension and preexisting anemia, tissue perfusion was adequately maintained. Neither cardiac conductance disturbances nor myocardial depression occurred. There was no evidence for major organ or organ system toxicity. The patient was successfully treated with intravenous calcium. Hemoperfusion did not significantly influence the clinical course. The recovery was uneventful. No late sequelae were observed.
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Schiffl et al. (1984) studied this question.
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