Key result
L-HBOT increases glutathione peroxidase activity ~149% vs quiet state in healthy dogs.
Why the study?
The influences of hyperbaric oxygen therapy with lower pressure and oxygen concentration on physiological mechanisms in dogs have not been clarified.
Does L-HBOT alter physiological mechanisms (blood gas, GPx, HRV, stress hormones, SC) in clinically normal dogs?
RCT (n=4)
Randomized crossover trial
No
Does L-HBOT alter physiological mechanisms (blood gas, GPx, HRV, stress hormones, SC) in clinically normal dogs?
Absolute Event Rate: 62.2% vs 25%
p-value: p=<0.01
L-HBOT in dogs may activate antioxidant enzymes and restrain autonomic nervous activity without significantly altering oxygenation dynamics.
Supports potential antioxidant effects of L-HBOT in dogs; hypothesis-generating and should not yet change veterinary practice.
Recently, hyperbaric oxygen therapy with a lower pressure and oxygen concentration (L-HBOT) than previous methods has been used for dogs in Japan; however, the influences of L-HBOT on dogs have not been clarified. To verify the influences of L-HBOT on physiological mechanism in dogs, we investigated blood gas parameters, glutathione peroxidase (GPx) activity, heart rate variability, stress-related hormones and skin conductance (SC) in 4 clinically normal beagle dogs with catheters in their carotid arteries and jugular veins when they were quiet, after running, after receiving L-HBOT (30% oxygen concentration, 1.3 atmospheres absolute, 30 min) or after not receiving L-HBOT. The results showed there were no changes in blood gas parameters, heart rate variability and catecholamine levels after L-HBOT. GPx activity was significantly higher, and the SC and cortisol level were lower in dogs that received L-HBOT than those when they were quiet. These results suggested that L-HBOT may have a small influence on oxygenation dynamics, activate antioxidant enzymes such as GPx, restrain autonomic nervous activity and control the balance between oxidation and antioxidation inside the body.
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Ishibashi et al. (2014) conducted an RCT in Clinically normal (n=4). L-HBOT (hyperbaric oxygen therapy with lower pressure and oxygen concentration) vs. Quiet state / non L-HBOT was evaluated on Glutathione peroxidase (GPx) activity (nmol/min/ml) (p=<0.01). L-HBOT significantly increased glutathione peroxidase activity to 62.2 nmol/min/ml compared to 25.0 nmol/min/ml in the quiet state (p<0.01) in healthy beagle dogs.