CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment

2][13] Gain-of-function mutations of CCR4 have been reported in ATL, associated with alterations at the carboxyl terminus [14][15][16] ; therefore, the aim of the present study was to determine their significance for responsiveness of such patients in the mogamulizumab era.We analyzed tumor samples from 116 patients with ATL.Diagnosis and assignment of clinical subtypes of ATL were conducted according to Japan Lymphoma Study Group recommendations. 17Tumor samples were obtained at the time of initial presentation at the hospital, and we used the clinical characteristics recorded at that time as baseline data.