Key Points Due to the higher affinity of current MCL-1 inhibitors, huMcl-1 mice have been established. A therapeutic window for S63845 can be established in huMcl-1 mice transplanted with huMcl-1;Eµ-Myc lymphomas.
No takes yet. Share an insight, caveat, or question.
Brennan et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: