Key result
Tropical endomyocardial fibrosis shows cardiac tissue changes similar to endomyocardial disease with eosinophilia.
Why the study?
Electron microscopic changes in cardiac tissue of patients with tropical endomyocardial fibrosis were not well characterized.
Observational (n=7)
Electron microscopic changes in tropical endomyocardial fibrosis show similarities to lesions in endomyocardial disease with eosinophilia, suggesting a shared pathophysiological mechanism.
May suggest shared mechanisms in endomyocardial fibrosis; leaves open whether this informs diagnostics or trials.
Electron microscopic examination of cardiac tissue from seven patients with tropical endomyocardial fibrosis showed the endocardium to be replaced by maturing granulation tissue containing haphazardly arranged collagen bundles, smooth muscle cells, blood vessels and degranulated mast cells. Mature collagen was present on the luminal aspect of the granulation tissue. Myofibres showed mitochondrial swelling, lamella bodies, focal myocytoplasmic clearing and collapsed intercalated discs. Small calibre blood vessels exhibited endothelial swelling, areas of basement membrane duplication and collections of neutrophilic and eosinophilic leucocytes. Eosinophils showed alteration in granule morphology. These changes are similar to the lesions reported in endomyocardial disease with eosinophilia.
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Krishnaswami et al. (1984) conducted an observational in Tropical endomyocardial fibrosis (n=7). Tropical endomyocardial fibrosis was evaluated on Electron microscopic changes in cardiac tissue. Cardiac tissue from patients with tropical endomyocardial fibrosis showed granulation tissue, collagen bundles, and cellular changes similar to endomyocardial disease with eosinophilia.
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