Key result
Spirulina platensis suppresses cardiac oxidative stress in diabetic rats and improves function in non-diabetic controls.
Why the study?
The effects of Spirulina platensis treatment on glycemic-lipid profile, oxidative stress, lipid peroxidation, and cardiac performance in diabetic rats were investigated.
Does Spirulina platensis reduce oxidative stress and improve cardiac performance in a rat model of type 1 diabetes?
Does Spirulina platensis reduce oxidative stress and improve cardiac performance in a rat model of type 1 diabetes?
Spirulina platensis demonstrates antioxidant properties that reduce oxidative stress and lipid peroxidation in a rat model of type 1 diabetes.
Hypothesis-generating for Spirulina in diabetic cardiomyopathy; should not change clinical practice without human trials.
Spirulina platensis (SPI) is a microalga with a high content of functional compounds, such as phenolics, phycocyanins and polysaccharides that has been shown to have antioxidant, anti-inflammatory, hypoglycemic, neuro-protective and immunomodulatory effects. The objectives of the present work were to study the possible effects of SPI treatment on the glycemic-lipid profile, oxidative stress, lipid peroxidation and cardiac performance in diabetic rats. Diabetes was induced by streptozotocin (STZ) in male Wistar rats. In diabetic animals SPI, at a dose of 50 mg/kg/day, reduced lipid peroxidation, nitrite levels and lipids in plasma and tissues. SPI exhibited an effective improvement on +dP/dT and −dP/dT in non-diabetic rats. This study showed that SPI significantly suppressed nitrite generation and lipoperoxidation in the hearts of diabetic animals, as well as an improvement in the cardiac function in control SPI-treated rats which is consistent with several studies that demonstrated the protective effect of antioxidants on oxidative stress-mediated injury caused by reactive oxygen species (ROS) produced in diabetic myocardial tissues.
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Garcia et al. (2018) studied Type 1 Diabetes (n=32). Spirulina platensis vs. Untreated diabetic and non-diabetic controls was evaluated on Lipid peroxidation (MDA), nitrite levels, and plasma lipids (p=<0.05). Spirulina platensis at 50 mg/kg/day significantly suppressed nitrite generation and lipoperoxidation in the hearts of diabetic rats and improved cardiac function in non-diabetic control rats.
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