Key result
Higher indoxyl sulfate links to greater lipid and lower fibrous volume in non-culprit coronary plaques.
Why the study?
Uremic toxin has emerged as an important determinant of cardiovascular risk, but its relationship with coronary plaque composition is unclear.
Is serum indoxyl sulfate associated with lipid-rich coronary plaque composition assessed by IB-IVUS in patients with angina pectoris?
Cross-Sectional (n=47)
No
Is serum indoxyl sulfate associated with lipid-rich coronary plaque composition assessed by IB-IVUS in patients with angina pectoris?
Effect estimate: r=0.359
p-value: p=0.04
Serum indoxyl sulfate may serve as a novel biomarker for detecting lipid-rich coronary plaques in patients with angina pectoris.
May support indoxyl sulfate as a plaque biomarker in angina; hypothesis-generating and requires prospective validation before any clinical use.
BACKGROUND: Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS). METHODS AND RESULTS: IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site. 3-D IB-IVUS analysis was performed to determine percent lipid volume (LV) and fibrous volume (FV). We also measured serum uremic toxins (indoxyl sulfate [IS], asymmetric dimethylarginine [ADMA], and p-cresol [PC]). Glomerular filtration rate correlated with IS (r=-0.329, P=0.04), but did not correlate with ADMA or PC. Percent LV correlated with IS (r=0.365, P=0.02), but did not correlate with ADMA or PC. Percent FV also correlated with IS (r=-0.356, P=0.03), but did not correlate with ADMA or PC. On multivariate regression, only IS was associated with percent LV (r=0.359, P=0.04) and percent FV (r=-0.305, P=0.04) independently of potentially confounding coronary risk factors. CONCLUSIONS: Among the uremic toxins, serum IS might be a novel useful biomarker to detect and monitor lipid-rich coronary plaque on IB imaging.
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Yamazaki et al. (2015) conducted a cross-sectional in Angina pectoris (n=47). Serum indoxyl sulfate was evaluated on Percent lipid volume (LV) on integrated backscatter intravascular ultrasound (IB-IVUS) (r=0.359, p=0.04). Higher serum indoxyl sulfate levels were independently associated with increased percent lipid volume (r=0.359, P=0.04) and decreased percent fibrous volume in non-culprit coronary plaques.
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