Accessing the Brain: The Nose may Know the Way

It was with great interest we read the recent review titled ‘Drug transport across the blood-brain-barrier'.1 In this paper, Pardridge describes the challenge of bypassing the blood–brain barrier (BBB) to allow therapeutic molecules to access the central nervous system (CNS), a challenge long recognized as one of the major issues in developing new treatments for brain disorders. The paper focused on how molecules can be reengineered for BBB transport via carrier-mediated transport and molecular ‘Trojan horse' delivery to access receptor-mediated transfer systems within the BBB, an interesting and exciting approach to this problem.