Comparative studies of cyanoacrylate derivatives in vivo

Seven surgical adhesives were prepared; n‐butyl, 2‐ethylhexyl, and isopropyl cyanoacrylate monomers and several combinations of ethyl cyanoacrylate and a plasticizer (either di‐2‐ethylhexyl phthalate or tricresyl phosphate). These were implanted as a thin film over the entire circumference of the adventitia of 48 canine carotid arteries. Vicissitude of cyanoacrylate polymers in vivo and tissue reaction to the polymers were traced for 6 months and investigated histologically. All adhesives tested in this study were insoluble in vivo and more resistant to biodegradation than methyl cyanoacrylate polymer. Tissue reaction against n‐butyl, 2‐ethylhexyl, or isopropyl cyanoacrylate was essentially the same as against ethyl cyanoacrylate in quality and was not less in degree than ethyl cyanoacrylate in spite of having longer side chains than ethyl radical.