Shows that bone marrow mesenchymal stem cell therapy improves post-stroke neurological recovery in rats, suggesting gut microbiota regulation mediates functional repair.
BACKGROUND: As a cellular mode of therapy, bone marrow mesenchymal stem cells (BMSCs) are used to treat stroke. However, their mechanisms in stroke treatment have not been established. Recent evidence suggests that regulation of dysregulated gut flora after stroke affects stroke outcomes. AIM: To investigate the effects of BMSCs on gut microbiota after ischemic stroke. METHODS: A total of 30 Sprague-Dawley rats were randomly divided into three groups, including sham operation control group, transient middle cerebral artery occlusion (MCAO) group, and MCAO with BMSC treatment group. The modified Neurological Severity Score (mNSS), beam walking test, and Morris water maze test were used to evaluate neurological function recovery after BMSC transplantation. Nissl staining was performed to elucidate on the pathology of nerve cells in the hippocampus. Feces from each group of rats were collected and analyzed by 16s rDNA sequencing. RESULTS: was increased. CONCLUSION: BMSC transplantation is a potential therapeutic option for ischemic stroke, and it promotes neurological functions by regulating gut microbiota dysbiosis.
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Zhao et al. (2021) studied this question.
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