Key result
Intravenous ANF reduces basal and stimulated renal PGE2 release in anaesthetized dogs.
Why the study?
The effect of atrial natriuretic factor on renal prostaglandin E2 release in anaesthetized dogs was examined to understand its regulatory role.
Does atrial natriuretic factor reduce renal prostaglandin E2 release in anaesthetized dogs?
Does atrial natriuretic factor reduce renal prostaglandin E2 release in anaesthetized dogs?
Atrial natriuretic factor reduces both basal and alpha 1-adrenergic stimulated renal prostaglandin E2 release in an in vivo dog model.
ANF may modulate renal PGE2 in dogs; leaves open translation to human physiology or therapy.
Experiments were undertaken in two groups of barbiturate anaesthetized dogs to examine whether atrial natriuretic factor (ANF) exerts an effect on renal release of prostaglandin E2 (PGE2). In the first group, intravenous infusion of ANF (50 ng min-1 kg-1 body wt) reduced basal PGE2 release from 4.4 +/- 0.8 pmol min-1 to 1.8 +/- 0.7 pmol min-1. In the second group, intrarenal infusion of an alpha 1-adrenoceptor agonist, phenylephrine (2.5-6.75 micrograms min-1), raised PGE2 release from 2.7 +/- 0.5 pmol min-1 to 7.5 +/- 1.3 pmol min-1. During continuous alpha 1-adrenergic stimulation, intravenous infusion of ANF (100 ng min-1 kg-1 body wt) reduced PGE2 release to 3.5 +/- 1.0 pmol min-1. These results demonstrate that ANF reduces basal and alpha 1-adrenergic stimulated renal PGE2 release.
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Næss et al. (1992) studied this question. Atrial natriuretic factor (ANF) vs. Basal state or alpha 1-adrenergic stimulation alone was evaluated on Renal release of prostaglandin E2 (PGE2). Intravenous infusion of atrial natriuretic factor reduced both basal and alpha 1-adrenergic stimulated renal prostaglandin E2 release in anaesthetized dogs.
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