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December 22, 2021Microbiology SpectrumOpen Access

Reverted HIV-1 Mutants in CD4 + T-Cells Reveal Critical Residues in the Polar Region of Viral Envelope Glycoprotein

Wuxun Lu Tai-Wei Li Stacia Phillips Li Wu

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Abstract

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Our previous mutagenesis study revealed that serine at position 534 of HIV-1 Env is critical for viral infectivity. We found that HIV-1 Env containing serine to proline mutation at position 534 (S534P) are incapable of supporting virus-cell and cell-cell fusion.

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Cite This Study

Lu et al. (2021) studied this question.

synapsesocial.com/papers/6aacbda6ec0bdebd47258ff4 https://doi.org/10.1128/spectrum.01653-21

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