Synthesis and Pharmacological Evaluation of Some Novel 2-Mercapto Benzimidazole Derivatives

The present study is synthesis of derivatives of N'-(4-amino-5-sulfanyl-4H-1,2,4-triazole-3-yl)-2-(1H-benzimidazole-2-ylsulfanyl) acetohydrazide (IV). Antibacterial activity tested against the E. coli and A. Substilis. Biological activities conducted by disc diffusion method. Compound 2MB₁ , 2MB₃ , 2MB₅ inhibit the appreciable microbial growth while rest of the compound possess the moderate activities. Anti-inflammatory activity tested by reduces local edema induced in the rat paw by injection of phlogestic agent. Compound 2MB₁ , 2MB₈ , 2MB₅ , 2MB₃ and 2MB₆ exhibit satisfying anti-inflammatory activity while analgesic activity conducted by acetic acid induced writhing effect in mice while compound 2MB₁ , 2MB₄ and 2MB₇ having the good analgesic activity. The chemical structures of all newly synthesized compounds were confirmed by their IR, ¹H NMR and mass spectral data.