Pyoderma gangrenosum (PG) is a rare, inflammatory neutrophilic disease that is characterized by rapidly progressing, painful skin ulcers with peripheral, violaceous erythema and undermined borders.1-3 While the pathophysiology of PG has not been fully elucidated, pathogenesis has been largely attributed to pathergy. Upon trauma, keratinocytes release interleukin 36 (IL-36) which is thought to play a role in PG pathogenesis and neutrophil recruitment.4,5
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Guénin et al. (2023) studied this question.
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