Original Articles: Prostate Cancer: Experience With Radical Prostatectomy and Radiation Therapy for Localized Prostate Cancer at a Veterans Affairs Medical Center

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1995Original Articles: Prostate Cancer: Experience With Radical Prostatectomy and Radiation Therapy for Localized Prostate Cancer at a Veterans Affairs Medical Center Jackson E. Fowler, Nicholas T. Braswell, Prabhakar Pandey, and Linda. Seaver Jackson E. FowlerJackson E. Fowler More articles by this author , Nicholas T. BraswellNicholas T. Braswell More articles by this author , Prabhakar PandeyPrabhakar Pandey More articles by this author , and Linda. SeaverLinda. Seaver More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67627-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We assessed the actuarial survival of 357 patients with localized prostate cancer who were treated with radical prostatectomy or radiation therapy at a Veterans Affairs Medical Center between 1980 and 1991 and who were followed for a median of 59 months. During this period patients with clinical stages A2 and B tumors who had an anticipated life expectancy of 10 years or greater were generally treated with surgery. Patients with stages A2 and B tumors who were not candidates for surgery and those with stage C tumors were generally treated with radiation therapy. There were no significant differences among the cause specific, clinical disease-free and prostate specific antigen disease-free survival curves of patients with stages A2 and B tumors who were treated with radical prostatectomy (138) or radiation therapy (138) but the all cause and metastases-free survival curves favored the surgery group (p <0.000001 and 0.046, respectively). There was no significant difference between the all cause survival curves of the patients with stages A2 and B tumors and of 81 patients with stage C tumors who were treated with radiation therapy. However, the cause specific survival curves favored the patients with stages A2 and B tumors (p = 0.000007). This study demonstrates that there is a high risk of death from co-morbidities in a hospital based population of American veterans with localized prostate cancer who are not candidates for radical prostatectomy. References 1 : Recent results of management of palpable clinically localized prostate cancer. Cancer1993; 72: 310. Google Scholar 2 : High 10-year survival rate in patients with early, untreated prostatic cancer. J.A.M.A.1992; 267: 2191. Google Scholar 3 : Results of conservative management of clinically localized prostate cancer. New Engl. J. Med.1994; 330: 242. Google Scholar 4 : Histologic grading of primary prostatic cancer: a new approach to an old problem. J. Urol.1980; 123: 689. Link, Google Scholar 5 : Differences in values obtained with 2 assays of prostate-specific antigen. J. Urol.1988; 139: 762. Link, Google Scholar 6 : Serum PSA after anatomic radical prostatectomy. The Johns Hopkins experience after 10 years. Urol. Clin. N. Amer.1993; 20: 713. Google Scholar 7 : Serum PSA as a tumor marker for patients undergoing definitive radiation therapy. Urol. Clin. N. Amer.1993; 20: 737. Google Scholar 8 : External beam radiation treatment for prostate cancer: still the gold standard. Oncology1992; 6: 79. Google Scholar 9 : Status of radiation treatment of prostate cancer at Stanford University. Natl. Cancer Inst. Monogr.1988; : 47. Google Scholar 10 : Proceedings: the Veterans Administration Cooperative Urological Research Group's studies of cancer of the prostate. Cancer1973; 32: 1126. Google Scholar 11 : A structured literature review of treatment for localized prostate cancer. Prostate Disease Patient Outcome Research Team. Arch. Fam. Med.1993; 2: 487. Google Scholar 12 : VACURG randomised trial of radical prostatectomy for stages I and II prostate cancer. Veterans Administration Cooperative Urological Research Group. Urology1981; 17: 7. Google Scholar 13 : Treatment of advanced localised prostatic cancer by orchiectomy, radiotherapy, or combined treatment. Brit. J. Urol.1992; 70: 304. Google Scholar 14 : Radiation therapy versus delayed androgen deprivation for stage C carcinoma of the prostate. J. Urol.1984; 131: 901. Link, Google Scholar 15 : The risk of dying of prostate cancer in patients with clinically localized disease. J. Urol.1991; 146: 1040. Link, Google Scholar 16 : Total prostatectomy for clinically localized prostatic cancer: long-term results. J. Urol.1989; 141: 564. Link, Google Scholar From the Division of Urology, University of Mississippi Medical Center, Jackson, Mississippi© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKOHAN A, ARMENAKAS N and FRACCHIA J (2018) THE PERIOPERATIVE CHARGE EQUIVALENCE OF INTERSTITIAL BRACHYTHERAPY AND RADICAL PROSTATECTOMY WITH 1-YEAR FOLLOWUPJournal of Urology, VOL. 163, NO. 2, (511-514), Online publication date: 1-Feb-2000.Fowler J and Terrell F (2018) Survival in Blacks and Whites After Treatment for Localized Prostate CancerJournal of Urology, VOL. 156, NO. 1, (133-136), Online publication date: 1-Jul-1996.Fowler J, Terrell F and Renfroe L (2018) Co-Morbidities and Survival of Men with Localized Prostate Cancer Treated with Surgery or Radiation TherapyJournal of Urology, VOL. 156, NO. 5, (1714-1718), Online publication date: 1-Nov-1996. Volume 153Issue 3SMarch 1995Page: 1026-1031 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Jackson E. Fowler More articles by this author Nicholas T. Braswell More articles by this author Prabhakar Pandey More articles by this author Linda. Seaver More articles by this author Expand All Advertisement PDF downloadLoading ...