Key result
Mitral calcification and absent Aschoff nodules are linked to AF in pediatric RHD.
Why the study?
Rheumatic heart disease affects mitral valve microanatomy in children, and the relationship between histological changes and clinical valve failure criteria requires interpretation.
Observational (n=25)
Yes
Histological changes in excised mitral valves from children with rheumatic heart disease correlate significantly with specific clinical manifestations of valve failure, such as atrial fibrillation and mitral stenosis.
The present study aims to interpret the histological changes observed in surgically excised mitral valves, and to how those changes relate to the clinical criteria of valve failure. A retrospective study was performed on 25 children patients with RHD, who had mitral valve surgery between 2000 and 2004 at the GOTHI hospitals. A highly significant association was present between absence of Aschoff nodules and atrial fibrillation (p=0.0070). Mitral calcification was significantly associated with atrial fibrillation (p=0.0050), followed by double mitral dysfunction (p=0.0142). Valvular endothelial ulcerations were significantly associated with mitral stenosis (p=0.0129) and double mitral dysfunction (p=0.0100). Rheumatic heart disease continues to be an important cardiac problem afflicting the young population of Egypt. The disease has a definite effect on mitral valve microanatomy. Clinical-pathologic correlation is important in evaluating the extent of valvular affection.
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A 2007 study conducted an observational in Rheumatic heart disease (n=25). Histological changes in excised mitral valves was evaluated on Clinical criteria of valve failure (atrial fibrillation, mitral stenosis, double mitral dysfunction). Histological changes like absence of Aschoff nodules and mitral calcification were significantly associated with atrial fibrillation in children with rheumatic heart disease (p=0.0070 and p=0.0050).
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