Autopsy Findings in a Case of Lepromatous Leprosy Treated with Clofazimine

The fi rst recorded autopsy fi ndings are presented on a young person suffering from intractable lepra reaction treated for four months with clofazimine in a dose of 300 mg daily.Apart fram a generalized yellow colouration of fa tty tissue, brick red in muscle and viscera , extreme congestion and oedema of the mucosa of the small intestine was found, and considered not to be caused by any infectious agent.Deposits of clofazimine crystals were found in the intestinal mucosa . History and Clinicai FeaturesThe patient was 'l girl aged 12 years when she was first admitted in 1965 to the Central Leprosy Teaching and Research Institute, Chingleput, as a case of lepromatou s leprosy.After about ' five months of treatment with DOS, she absconded from the Institute.Seven yeais later, she re tumed with the disease very much advanced and wit .h severe lepra re action, She was treated initial i y with anti in alarials, and later with antimonial drugs, along with other remedies for relief of her symptoms.Ouring this period, she had mild albuminu ria with two to five pus cells per high power microscopic field.After abou t five months of medication