Key result
No proven agents prevent frequent restenosis driven by intimal hyperplasia after coronary angioplasty.
Why the study?
Restenosis after successful coronary angioplasty remains a frequent problem limiting long-term efficacy, with no proven effective preventive agents.
Restenosis due to intimal hyperplasia remains a major limitation of coronary balloon angioplasty, with pharmacological prevention strategies under investigation.
Restenosis after angioplasty persists without proven prevention; leaves open targeted trials of intimal hyperplasia inhibitors.
A recurrence of stenosis (restenosis) following successful coronary angioplasty continues to be a frequent problem limiting the long-term efficacy of the procedure. An overexuberant reparative response to the arterial injury induced by balloon dilatation leads to intimal hyperplasia, the major mechanism responsible for restenosis. Although none has yet been proven effective, agents designed to prevent this hyperplastic response are under investigation.
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Lange et al. (1991) conducted a review in Restenosis after coronary balloon angioplasty. Restenosis following coronary angioplasty remains a frequent problem driven by intimal hyperplasia, with no agents yet proven effective to prevent this response.
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