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Chromosome analysis in the cultured peripheral blood lymphocytes of multiple endocrine adenomatosis (MEA-II) patients and their siblings demonstrated a preponderance of higher frequency of metaphases with chromosome and chromatid type abnormalities (average, 11.0%) as compared to controls (average, 3.8%). Our preliminary data suggest that MEA-II patients exhibit some degree of chromosome instability. (JAMA1981;246:2046-2048)
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Tsai‐Ching Hsu (1981) studied this question.
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