Plasmapheresis with Plasma Exchange in Hepatic Coma.

s1 May 1969Plasmapheresis with Plasma Exchange in Hepatic Coma.Michael J. Lepore, M.D., F.A.C.P., Anthony J. Martel, M.D.Michael J. Lepore, M.D., F.A.C.P.Search for more papers by this author, Anthony J. Martel, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1069_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFailure of patients in hepatic coma to respond to hemodialysis or peritoneal dialysis and their improvement after exchange transfusions suggests that a protein-bound nondialyzable factor may be involved. Such a factor might be removed selectively by bleeding the patient, separating and discarding his plasma, and returning to him his own red cells plus fresh, frozen human plasma—that is, plasmapheresis with plasma exchange.We have used this technique in a series of patients with severe hepatic disease. This report describes our experience with this procedure in four patients in hepatic coma due to fulminant, massive hepatic necrosis. All four patients were... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1069-1069KeywordsBlood plasmaCellsComaHemorrhageNecrosisPeritoneal dialysisProteins Issue Published: 1 May 1969 PDF DownloadLoading ...