Antigen-rich mycelial extract (ME) and fractions of Aspergillus fumigatus were compared with culture filtrates of A. fumigatus. A. flavus, and A. niger for their abilities to detect antibody in serums from patients with confirmed aspergillosis caused by these fungi. In double immunodiffusion tests, homologous antigen preparations were more effective than heterologous preparations in detecting precipitins. Mycelial extract of A. fumigatus was more effective than A. fumigatus culture filtrate in detecting antibody in serums from patients with disease caused by A. flavus and A. niger. It did not, however, detect antibody in the serums from approximately half of the patients with heterologous infections.
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Chaparas et al. (1980) studied this question.