Total Synthesis of (+)-Nafuredin-γ Using a Highly Stereoselective Ti-Mediated Aldol Reaction

An efficient total synthesis of (+)-nafuredin-γ has been achieved in 10 steps from (E)-3-(tributylstannyl)propenal. The synthesis features direct construction of an anti-1,2-diol moiety via a Ti-mediated aldol reaction of lactyl derivative and rapid fragment assembly, which relied on well-established Pd chemistry.