Isotopically Labelled Phosphorus Compounds: Some Deuterated Methyl and Ethyl Derivatives

The synthesis of fifteen phosphylated compounds having P─OCD3, P─CD3, or P─OCD2CH3 groups is described. Selective chemistry for the precise placement of the deuterated groups was devised, and the products were isolated in a high purity in generally good yields. The compounds were required to study their behavior after electrospray ionization in an ion trap mass spectrometer.