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A method to evaluate nucleation and crystal growth rates from batch cooling crystallization experiments is presented. Solute concentration and suspension temperature are recorded during the experiment and the product crystal size distribution is analyzed. The crystal growth and nucleation rates at any instant are calculated by solving the population balance equation using the method of characteristics, together with the mass balance equation. Based on a set of different cooling crystallization experiments, kinetics for succinic acid are determined. Applying these kinetics in process simulation allows for a reasonably accurate prediction of the product weight mean size.
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Qiu et al. (1991) studied this question.
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