Key result
Retinopathy in normoalbuminuric T1D is linked to ~54% lower forearm reactive hyperaemia.
Why the study?
Is the forearm vasodilatory response to reactive hyperaemia reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with those without retinopathy?
Population
39 normoalbuminuric subjects with long-standing Type 1 diabetes mellitus (22 with retinopathy).
Comparison
Presence of retinopathy (observational exposure) vs Subjects with no retinopathy
Design
Cross-sectional
Authors
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May indicate early endothelial dysfunction in T1DM retinopathy; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=39)
Is the forearm vasodilatory response to reactive hyperaemia reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with those without retinopathy?
Absolute Event Rate: 219% vs 473%
p-value: p=<0.01
Retinopathy in Type 1 diabetes is associated with reduced forearm reactive hyperaemia, suggesting generalized endothelial dysfunction even before the onset of microalbuminuria.
Gibney et al. (2004) conducted a cross-sectional in Type 1 diabetes mellitus (n=39). Retinopathy vs. No retinopathy was evaluated on Forearm reactive hyperaemia (RH) (p=<0.01). Retinopathy in normoalbuminuric subjects with Type 1 diabetes was associated with significantly decreased forearm reactive hyperaemia compared to those without retinopathy (219 vs 473, P<0.01).
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