Key result
Campus syndrome gene mapping suggests a porcine model for human dominant distal myopathy type 1.
Why the study?
A new progressive tremor disorder called Campus syndrome (CPS) was observed in pigs, and its inheritance pattern and genetic location were unknown.
Answers are grounded in this paper and cite their sources.
Campus syndrome in pigs maps to a region homologous to human chromosome 14, suggesting it may serve as an animal model for human dominant distal myopathy type 1 (MPD1).
A new progressive tremor disorder called Campus syndrome (CPS) was observed among the progeny of a normal boar of the Pietrain breed in Germany. Extensive backcross experiments indicate that CPS is inherited as an autosomal dominant trait, and the founder boar, Campus, is believed to be a gonadal mosaic. A linkage analysis of 57 animals mapped the CPS gene to a region on porcine chromosome 7 flanked by the markers SW1418 and SW352, which is homologous to a part of human chromosome (HSA) 14. Human dominant distal myopathy type 1 (MPD1) has been mapped to the homologous region of HSA14. As the myopathological findings in MDP1 show striking similarities to CPS, this porcine disorder may serve as an animal model for MPD1.
No takes yet. Share an insight, caveat, or question.
Imke Tammen (1999) studied Campus syndrome (CPS) (n=57). Genetic mapping was evaluated on Genetic mapping of the CPS gene. Linkage analysis mapped the Campus syndrome gene to a region on porcine chromosome 7 homologous to human chromosome 14, suggesting it as an animal model for human dominant distal myopathy type 1.
Synapse has enriched 10 related papers. Consider them for comparative context: