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A Lewis acid catalyzed tandem nucleophilic addition/oxa‐Michael reaction was developed for the synthesis of cis‐2,6‐disubstituted tetrahydropyran (THP) derivatives in good yields with excellent diastereoselectivities. The strategy was successfully used in the construction of THP derivatives with three stereocenters in a highly stereoselective fashion.
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Gharpure et al. (2014) studied this question.
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