Key result
Nocturnal oxygen desaturation affects ~29% of moderate-to-severe COPD patients and is linked to lower PaO2.
Why the study?
The presence of nocturnal hypoxemia has been postulated as an etiopathological factor in the development of pulmonary hypertension in COPD patients.
Observational (n=100)
No
Absolute Event Rate: 61.54% vs 70.65%
p-value: p=<0.001
A significant proportion (29%) of normoxemic COPD patients experience nocturnal desaturation, which may contribute to the development of pulmonary hypertension.
Nocturnal desaturation may occur despite normoxemia in COPD; leaves open whether PaO2/PaCO2-guided screening alters pulmonary hypertension risk or outcomes.
Aim of the study: To study presence of nocturnal oxygen desaturation with pulmonary hypertension. Results: The mean age of patients was 69.51 years. The mean duration of COPD was 4.14 years. The mean smoking index of study population was 401.32. Mean baseline SPO2. The mean BMI was 26.32 kg/m2. The mean hemoglobin level was 11.21 g/dL. The partial pressure of oxygen and carbon dioxide in desaturators and nondesaturators was 61.54 mmHg and 70.65 mmHg respectively. The presence of nocturnal hypoxemia has been postulated as the etiopathological factor resulting in the development of pulmonary hypertension in COPD patients. Conclusion: From the results of the present study, this can be concluded that 29 % of the normoxemic patients had significant nocturnal desaturation. The significant predictors of nocturnal desaturation are PaO2 and PaCO2.
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Mohd Akram Qureshi (2020) conducted an observational in Moderate to severe COPD (n=100). Nocturnal oxygen desaturation vs. Non-desaturators was evaluated on Partial pressure of oxygen (PaO2) in mmHg (p=<0.001). In patients with moderate to severe COPD, nocturnal oxygen desaturation was present in 29% of patients and was significantly associated with lower PaO2 (61.54 vs 70.65 mmHg, p<0.001).
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