Treatment of Chloroquine-resistant Plasmodium falciparum Infections in Vietnam

Editorials1 March 1967Treatment of Chloroquine-resistant Plasmodium falciparum Infections in VietnamTHOMAS W. SHEEHY, RICHARD C. REBATHOMAS W. SHEEHYSearch for more papers by this author, RICHARD C. REBASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-3-616 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Moore And Lanier's (1) report of two patients with chloroquine-resistantPlasmodium falciparuminfections acquired in the Magdalena Valley of Columbia in 1961, a fear has existed among malariologists that large-scale outbreaks of resistant malignant tertian malaria might develop. This fear was increased considerably by the discovery of strains of chloroquine-resistantP. falciparumin four countries of Southeast Asia between 1961 and 1963, and it was realized in the autumn of 1965 when the U. S. Army began extensive field operations in Southeast Asia. Shortly after combat units began probing the remote forested areas of the Ia-Drang and Vinh-Thanh Valleys...References1. MOORELANIER DVJE: Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine. Amer. J. Trop. Med. 10: 5, 1961. CrossrefMedlineGoogle Scholar2. DEGOWINPOWELL RLRD: Drug resistance of a strain of Plasmodium falciparum from Malaya. Amer. J. Trop. Med. 14: 519, 1965. CrossrefGoogle Scholar3. YOUNGCONTACOSSTITCHERMILLAR MDPGJEJW: Drug resistance in Plasmodium falciparum from Thailand. Amer. J. Trop. Med. 12: 305, 1963. CrossrefMedlineGoogle Scholar4. LEGTERSWALLACEPOWELLPOLLACK LJDKRDS: Apparent refractoriness to chloroquine, pyrimethamine, and quinine in strains of Plasmodium falciparum from Vietnam. Milit. Med. 130: 168, 1965. CrossrefMedlineGoogle Scholar5. HURLY MG: Potentiation of pyrimethamine by sulfadiazine in human malaria. Trans. Roy. Soc. Trop. Med. Hyg. 53: 412, 1959. 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Human Antiparasitic AgentsMalaria — Recent Progress and ProblemsAcquired decrease in sensitivity to quinine observed during studies with a strain of chloroquine-resistant Plasmodium falciparumClinical experience with sulphadiazine and pyrimethamine in the treatment of persons experimentally infected with chloroquine-resistant Plasmodium falciparumMalarial TransfusionsMARCEL E. CONRAD 1 March 1967Volume 66, Issue 3Page: 616-622KeywordsFearMalariaPlasmodium falciparum Issue Published: 1 March 1967 PDF DownloadLoading ...