Daily or Intermittent Budesonide in Preschool Children With Recurrent Wheezing

RS Zeiger, D Mauger, LB Bacharier. N Engl J Med. 2011;365(21):1990–2001 To compare the efficacy of daily low-dose inhaled glucocorticoids versus intermittent high-dose inhaled glucocorticoids in children at risk for asthma exacerbations. Children ( n = 278) in the study were between the ages of 12 and 53 months with positive values on the modified asthma predictive index (API), recurrent wheezing episodes, and at least 1 exacerbation in the previous year, but a low degree of impairment. Children were excluded from the study if they had received more than 6 courses of oral glucocorticoids or had been hospitalized more than 2 times …