Synthesis of Enopeptin B from Streptomyces sp RK‐1051

This is the authors' abstract. We don't add key points for this paper.

A cyclopeptolide, a polyene, and an aminoreductone—species with completely different biogenetic origins—are the components of the antibiotically active natural product enopeptin B (1, see schematic representation below), which is particularly active against Staphylococcus aureus. The first total synthesis of this compound, which belongs to a new class of substances, was achieved by the clever use of the arsenal of methods available to modern peptide chemistry. The three basic units were coupled by two different routes.