A series of random poly(ester amide)s with different chemical compositions and derived from sebacoyl dichloride, 1,6-hexanediamine and 1,6-hexanediol was synthesized and characterized. In addition, a poly(ester amide) with equal ratio of 1,12-dodecanediamine and 1,12-dodecanediol units was prepared. All these poly(ester amide)s were obtained by interfacial polymerization with high yields. Thermal behavior, mechanical properties, crystallinity and degradability were studied and compared with the parent polyesters (6,10 and 12,10) and nylons (6,10 and 12,10). The new poly(ester amide)s were hydrolyzable, the degradation rate depending on the ester/amide ratio and the methylene content of the diol or diamine units. On the contrary, they were not degraded with proteolytic enzymes. This observation contrasts with the behavior of related poly(ester amide)s that include α- amino acid units in their composition.
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Armelín et al. (2002) studied this question.