Shows diminished TLR2 activation and interleukin-1β production by Porphyromonas gingivalis ATCC 33277 versus 381, highlighting strain-specific bacterial immune modulation.
The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting that there are strain-specific differences in one or more bacterial immune-modulatory factors.
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Coats et al. (2019) studied this question.
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