Nitrogen-15 spin-lattice relaxation times (T_1's) and nuclear Overhauser enhancement (NOE) values are found to vary over a range of concentrations for acetamide. Our data indicate that intermolecular amide-amide hydrogen bonds are broken on dilution in water. Carbon-13 spin-lattice relaxation times and nuclear Overhauser enhancement measurements are given for acetamide and N,N-dimethylacetamide at 5.3 M. There is good agreement between experimental and calculated relaxation rates assuming rapid rotation of the α methyl group and slow rotation about the amide bond.
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Giannini et al. (1975) studied this question.