Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing

Benjamin Kreck; Julia Richter; Ole Ammerpohl; Matthias Barann; Daniela Esser; Britt Petersen; Inga Vater; Eva Maria Murga Penas; Christina A. Bormann Chung; Stefanie Seisenberger; Victoria L. Boyd; Sébastien A. Smallwood; Hans G. Drexler; Roderick A.F. MacLeod; Michael Hummel; Felix Krueger; Robert Häsler; Stefan Schreiber; Philip Rosenstiel; André Franke; Reiner Siebert

doi:10.1038/leu.2013.4

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Abstract

The Burkitt translocation t(8;14), first identified in the 1970s in biopsies and cell lines from Burkitt lymphoma (BL), 1 , 2 and its variants juxtapose the MYC oncogene to one of the immunoglobulin ( IG ) loci. 3 Nowadays, it is assumed that (nearly) all BL carry an IG-MYC translocation, rendering this somatic mutation a diagnostic marker for all three subtypes of BL (endemic, sporadic and immunodeficiency-related BL).

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Kreck et al. (2013) studied this question.

synapsesocial.com/papers/6aacedd384308b7f2b3fe418 https://doi.org/10.1038/leu.2013.4

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Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing

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Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing

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