Key result
Multidomain intervention targeting vascular risk factors fails to reduce dementia incidence versus usual care.
Why the study?
The association of multidomain interventions targeting vascular risk factors with dementia incidence among older adults was investigated to address dementia prevention.
Do multidomain interventions targeting vascular risk factors reduce dementia incidence in community-dwelling older adults?
RCT (n=3,526)
Single-blind (outcomes assessor masked)
Randomized
Yes
Do multidomain interventions targeting vascular risk factors reduce dementia incidence in community-dwelling older adults?
This study investigates whether targeting vascular risk factors through multidomain interventions can reduce dementia incidence in older adults.
This follow-up analysis of a randomized clinical trial investigates the association of multidomain interventions targeting vascular risk factors with dementia incidence among community-dwelling older adults.
No takes yet. Share an insight, caveat, or question.
Hoevenaar‐Blom et al. (2021) conducted an RCT in Dementia (n=3,526). Multidomain intervention targeting vascular risk factors vs. Usual care was evaluated on Dementia incidence (HR 0.99, 95% CI 0.89-1.10, p=.92). A multidomain intervention targeting vascular risk factors did not significantly reduce dementia incidence compared to usual care over a median follow-up of 10.3 years (HR 0.99, 95% CI 0.89-1.10, P = .92).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: