Key result
Newer platelet concentrates like PRF provide advanced tissue regeneration alternatives but lack standardized protocols.
Why the study?
Variability in protocols and factors affecting platelet concentrates leads to evolving methods and properties, requiring clarification of their differences and clinical applications.
This review summarizes the evolution, preparation protocols, and clinical applications of platelet concentrates in regenerative therapy.
Protocol variability may alter growth factor distribution in platelet aggregates; leaves open standardization for consistent regenerative outcomes.
Platelet aggregates are solutions derived from autologous blood submitted to the centrifugation and utilized to aid the tissue regeneration.The protocols of obtaining such solutions depend on several factors such as the radius of the centrifuge's rotor, the strength and the time of rotation, and the tube's material that are utilized.Taking in account the variability of the factors that interfere in the distribution of the growth factors present, the platelet aggregates evolve in each new method created, also altering its properties and there for its clinical applications, being able to associate to bone grafts, injected, utilized in wound covering, and there for, capable to aid in the regeneration of varied tissues.This review proposes to reunite and describe details about the procedures that compose the different types of platelet concentrates and their respective utilities in the sub-areas of healthcare in general.For this reason, a bibliographical research was made in chronological order taking upon as its starting point the creation of the fibrin glue and following until the most recent studies of which describe modern alternatives for regenerative therapy and coagulation simulation, in addition to publication of structural texts for clarification of the homeostasis mechanism, platelet anatomy and function, growth factors, and laboratory good practices when the procedure of the blood gathering and processing and subsequent application of the platelet aggregate created.It is hoped that this work may clarify the main divergences among the platelet aggregates, focusing in growing technologies.
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Oliveira et al. (2022) conducted a review in Tissue regeneration and wound healing. Platelet concentrates (PRP, PRF, and variations) was evaluated. Newer generations of platelet concentrates, such as Platelet-Rich Fibrin (PRF) and its variations, provide advanced alternatives for tissue regeneration, though standardized protocols remain lacking.
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