Key result
Acute lower extremity arterial occlusion with myoglobinuria linked to fatal tubular necrosis in ~50% of cases.
Why the study?
Acute arterial occlusion of the lower extremity associated with massive ischemic myopathy and myoglobinuria can lead to severe local signs and fatal renal tubular necrosis, but detailed clinical descriptions are limited.
Case Report (n=4)
Acute arterial occlusion of the lower extremity can lead to massive ischemic myopathy and myoglobinuria, which may result in fatal tubular necrosis.
Answers are grounded in this paper and cite their sources.
Alerts to fatal renal risk in acute arterial occlusion; hypothesis-generating from small case series.
Four cases of acute arterial occlusion of the lower extremity associated with massive ischemic myopathy and myoglobinuria are reported. Clinically, there were four characteristic manifestations: excruciating pain; severe and extensive ischemia of the tissues; rigidity of the extremity with stiffness of joints; and massive edema. The widespread ischemic myopathy of the extremity is a probable underlying cause of the severity of the local signs. Myoglobinuria was found in the four cases and accounts for the fatal tubular necrosis (myoglobinuric nephrosis) in two patients.
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Henry Haimovici (1970) conducted a case report in Acute arterial occlusion of the lower extremity associated with massive ischemic myopathy and myoglobinuria (n=4). Acute arterial occlusion of the lower extremity was evaluated on Fatal tubular necrosis (myoglobinuric nephrosis). Acute arterial occlusion of the lower extremity with massive ischemic myopathy and myoglobinuria resulted in fatal tubular necrosis in 2 of 4 reported cases.
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