Percentage incidences of toxic effects of chemotherapy Symptoms Marrow depression Nausea or vomiting or both Mild 38 WBC 2 5-4O0 x 10;/1 46 ~~~~~~~~Svr 5 WBC <2-5 x 1091..2 Oral ulceration .4Platelets 75-100 x 109,11 .. .. 6 Hepatotoxicity .. 2 Platelets <75 x 109 1 .. .. 2 Alopecia .. 3 Diarrhoea .. 6 Gastrointestinal bleeding.2 Dermatitis .. 2toxicity with the two agents have stimulated us to progress to a three- drug regimen of melphalan, methotrexate, and 5-fluorouracil in a further attempt to devise a treatment with high acceptability and low toxicity.The findings will be reported.Advancing the management of early breast cancer is so complex that progress can be made only by multicentre studies.Evidence on toxicity with the moderate drug regimen should encourage other clinicians to participate.We thank all the clinicians in the trial for their help and support in this preliminary study.
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Majumdar et al. (1978) studied this question.