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September 18, 2026JACC Heart FailureOpen Access

Trends in Glucagon-Like Peptide-1 Receptor Agonist Prescriptions in Heart Failure With Reduced Ejection Fraction

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Authors

CZCarolina Pires ZinganoBSBernardo F. SpiazziGBGeorge Blankson

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Overview

Observational analysis reveals prescription patterns of GLP-1 receptor agonists in heart failure with reduced ejection fraction, highlighting evolving clinical adoption across cardiometabolic care.

Key Points

  • To evaluate longitudinal patterns and temporal trends in glucagon-like peptide-1 receptor agonist prescriptions among patients diagnosed with heart failure with reduced ejection fraction.
  • Analyzed clinical prescription registries and dispensing records for glucagon-like peptide-1 receptor agonists over time.
  • Identified cohorts of individuals with documented heart failure with reduced ejection fraction.
  • Identified directional shifts and temporal adoption rates in glucagon-like peptide-1 receptor agonist utilization across clinical practice.
  • Characterized changes in prescriber behavior aligning with updated safety evidence and professional society guideline recommendations.

Cite This Study

Zingano et al. (2026) studied this question.

synapsesocial.com/papers/6aacf7740c46fbdff987ddbdhttps://doi.org/10.1016/j.jchf.2026.103318
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