Alteration of MCP-1 and MMP-9 in Aqueous Humor Is Associated with Secondary Glaucoma in Fuchs Uveitis Syndrome

This is the authors' abstract. We don't add key points for this paper.

D. Bauer PhD1** , M. Kasper PhD1* , K. Walscheid MD1, J. M. Koch MD1, P. S. Müther MD2, B. Kirchhof MD2, A. Heiligenhaus MD13 & C. Heinz MD13 1 Department of Ophthalmology and Ophtha-Lab, St. Franziskus Hospital Münster, Münster, Germany2 Center for Ophthalmology, University Cologne, Köln, Germany3 Center for Ophthalmology, University of Duisburg-Essen, Essen, GermanyCorrespondence: D. Bauer, Department of Ophthalmology and Ophtha-Lab, St. Franziskus-Hospital Münster, Hohenzollernring 74, Münster 48145, Germany. E-mail: dirk.bauer@uveitis-zentrum.de* Shared first authorship.Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ioii.ABSTRACTPurpose To analyze changes in concentrations of pro- or anti-inflammatory cytokines, chemokines, or metalloproteinases (MMP) in the aqueous humor (AH) in Fuchs uveitis syndrome (FUS) patients with (FUSwG) or without (FUSwoG) secondary glaucoma.Methods AH samples were collected from 43 eyes of Caucasian subjects (FUSwoG: n = 11; FUSwG: n = 8; control eyes: n = 24). Concentrations of IL-8, MCP-1, MMP-1,-2,-3,-9, SAA, TGFß-1,-2,-3, and TNF-α were measured by multiplex bead assay analysis.Results Compared with the control group, levels of IL-8, MCP-1, MMP-3, and MMP-9 in the AH were significantly increased in FUSwG and FUSwoG patients. In contrast to FUSwoG patients, MCP-1 and MMP-9 level were lower in FUSwG, while expression of MMP-2, MMP-3, and TGFβ-1 was increased.Conclusion In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased. The alteration in these molecular patterns may contribute to the development of glaucoma in FUS.