The serum levels of squamous cell carcinoma-related antigen (SCC-RAG) were assayed in 15 cases of benign dermatoses. The SCC-RAG titers (2.0 ng/ml as the cutoff value) were elevated in all cases of wide-spreading psoriasis (7 cases, 2.4-96.1 ng/ml) and all cases of generalized eczema (3 cases, 11.2-33.6 ng/ml). The serum SCC-RAG levels correlated with clinical course of these dermatoses. Therefore, the increase in this cancer-related antigen is not specific for SCC but may also occur in a wide range of dermatoses.
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Numahara et al. (2009) studied this question.