Under pressure: Panduratin A (1) has been synthesized in six steps including a high pressure Diels–Alder reaction. This divergent sequence also allowed the synthesis of 4-hydroxypanduratin A, panduratin H, panduratin I, nicolaioidesin B, and 2-hydroxyisopanduratin A. The binding of panduratin A to the dengue virus NS2B-NS3 protease was investigated by NMR spectroscopy.
No takes yet. Share an insight, caveat, or question.
Pasfield et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: