Protected forms of trans-β-ocimene and α-farnesene where synthesized in one step by direct deprotonation of 2,5-dihydro-3-methylthiophene-1,1-dioxide (6) followed by alkylation with suitable allylic bromides; this approach provides a regioselective and stereoselective introduction of an isoprene unit onto a pre-existing skeleton.
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Chou et al. (1984) studied this question.